New York City Back Pain Related to Inflammation Reduced with Melatonin
Inflammation. Disc Degeneration. There is a relationship. Inflammation is the body’s response to harmful stimuli (injury, pathogens, metabolic stress – a disc herniation compressing a nerve!) as it attempts to repair itself before the harm was done. Rosenberg Wellness Center is always amazed at what the body can do! Rosenberg Wellness Center sees its New York City chiropractic care as a partner of the body’s system in healing especially when spine pain is an issue. Chiropractic care utilizes many tools like spinal manipulation, exercise, and nutrition to take care of the body. Melatonin is one nutritional tool that is proving value in its ability to interrupt the inflammatory process related disc herniation that brings about pain relief: back, neck, spine-related.
DISC DEGENERATION AND INFLAMMATION AND 'AUTOPHAGY'
Inflammatory markers interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are associated with intervertebral disc degeneration. (1) IL-1 β in fact promotes itself, its own expression, by upregulating NLRP3 inflammasome activation. (2) The body controls itself down to its cellular level via autophagy, the natural process via which the body’s cells clear out damaged (ie, by inflammation) or unneeded parts. In a recent study, melatonin increased autophagy and decreased the degradation of the disc’s extracellular matrix (technically indicated by a decline in marker LC3B, autophagasomes and autolysosomes and inhibition of the NF-kB signaling pathway). The final conclusion was that melatonin inhibits intervertebral disc degeneration by promoting autophagy. (3) Wow. Rosenberg Wellness Center is encouraged by this research to see just how well melatonin can work for New York City back pain related to disc degeneration.
MELATONIN AND ITS HEALING WAYS FOR THE DISC
Disc degeneration is quite a common condition seen at Rosenberg Wellness Center that positive news of melatonin’s benefits are quite exciting. A recent study described that melatonin could modify the extracellular matrix of the disc remodeling process initiated by IL-1 β. Further, melatonin decreased the inflammatory cell collection and reduced the release of linked inflammatory markers IL-1β, IL-6, and TNF-α. With this new discovery that melatonin interrupted the IL-1B feedback loop, researchers proposed that melatonin may support the restoration process of intervertebral discs after damage was already present. (1) Rosenberg Wellness Center continues following the new research regarding the role inflammation performs in New York City disc degeneration and melatonin’s role in combatting it.
INFLAMMATION AND MELATONIN
The importance of melatonin in helping to slow or stop painful conditions due to inflammation is growing. The description of melatonin as a multitasking molecule influencing mood, immunity, and energy among other mechanisms is quite apropos. It is also anti-oxidant, anti-aging, and anti-inflammatory, specifically by hindering the activation of inflammasomes (4) Melatonin’s formal chemical name is as about as long as its list of tasks: N-acetyl-5-methoxytryptamine. The pineal gland produces melatonin naturally. Melatonin impacts the body’s aging, anti-inflammatory, anti-apoptosis (cell death), and autophagy (cell-cleanout) processes. (1) Melatonin’s specific influence on inflammation and disc degeneration is most interesting to Rosenberg Wellness Center and our New York City back pain patients.
CONTACT Rosenberg Wellness Center
Listen to this PODCAST with Dr. Hrefna Sylvia based in Iceland where back pain isn’t much different from any other country on The Back Doctors Podcast with Dr. Michael Johnson as she describes how The Cox® Technic System of Spinal Pain Management addresses disc degeneration for relief of chronic low back pain in her patient.
Schedule your New York City chiropractic appointment with Rosenberg Wellness Center today. We can discuss the role inflammation plays in your back pain experience and how melatonin may help with the related disc degeneration.
